Earlier work on the biosynthesis of morphine in the opium poppy, Papaver somniferum, is reviewed in chapter I. A variety of unnatural codeine precursors, closely related structurally to codeine and labelled with 3H at C-2, have been prepared and administered to P. somniferum plants. Their in vivo 3-0-demethylation to give the corresponding morphine compounds was investigated using radiodilution techniques. Each of the feeding experiments utilised [N-methyl-14C]codeine as an internal standard and the efficiency of the unnatural 3-0-demethylations was compared with that observed for the natural conversion of codeine into morphine. Dihydrodesoxycodeine was more efficiently converted into dihydrodesoxymorphine than was codeine into morphine. Th...
Laudanosoline-4':6-dimethyl ether has been postulated as the phenolic precursor in the biogenesis of...
The synthesis of codeinone enol ethers from thebaine, via acetals of 14beta-bromocodeinone, has been...
The conversiomi of codeine to morphine has beemi shown to occur in man and rat by Adler and Latham (...
The present thesis describes our latest results in the chemistry of morphine alkaloids. An enantiod...
ConspectusWe became interested in approaches to morphine in the early 1990s following our immersion ...
VOLUME. 1: Published papers1. The morphine group. Part 1. || 2. The morphine group. Part 2. || ...
SummaryOpium poppy (Papaver somniferum) produces medicinally important benzylisoquinoline alkaloids,...
AbstractStandard samples of pure (+)-salutaridine and (−)-thebaine required to study the mammalian o...
Dedicated to Dr. Alfred Bader on the occasion of his 85th birthday. Morphine alkaloids and some of i...
The purpose of the study was to determine the ability of certain fungi to biotransform morphine alk...
Nitrosation of thebaine using nitrosyl chloride, pentyl nitrite and nitrosyl sulphuric acid was inve...
Opium poppy (Papaver somniferum) produces medicinally important benzylisoquinoline alkaloids, includ...
It is known that morphine-6-glucuronide is more potent than morphine, but it is difficult and expens...
Research Council a sum of money to be used for the study of drug addiction. Accordingly, the Researc...
Opium poppy (Papaver somniferum) produces medicinally important benzylisoquinoline alkaloids, includ...
Laudanosoline-4':6-dimethyl ether has been postulated as the phenolic precursor in the biogenesis of...
The synthesis of codeinone enol ethers from thebaine, via acetals of 14beta-bromocodeinone, has been...
The conversiomi of codeine to morphine has beemi shown to occur in man and rat by Adler and Latham (...
The present thesis describes our latest results in the chemistry of morphine alkaloids. An enantiod...
ConspectusWe became interested in approaches to morphine in the early 1990s following our immersion ...
VOLUME. 1: Published papers1. The morphine group. Part 1. || 2. The morphine group. Part 2. || ...
SummaryOpium poppy (Papaver somniferum) produces medicinally important benzylisoquinoline alkaloids,...
AbstractStandard samples of pure (+)-salutaridine and (−)-thebaine required to study the mammalian o...
Dedicated to Dr. Alfred Bader on the occasion of his 85th birthday. Morphine alkaloids and some of i...
The purpose of the study was to determine the ability of certain fungi to biotransform morphine alk...
Nitrosation of thebaine using nitrosyl chloride, pentyl nitrite and nitrosyl sulphuric acid was inve...
Opium poppy (Papaver somniferum) produces medicinally important benzylisoquinoline alkaloids, includ...
It is known that morphine-6-glucuronide is more potent than morphine, but it is difficult and expens...
Research Council a sum of money to be used for the study of drug addiction. Accordingly, the Researc...
Opium poppy (Papaver somniferum) produces medicinally important benzylisoquinoline alkaloids, includ...
Laudanosoline-4':6-dimethyl ether has been postulated as the phenolic precursor in the biogenesis of...
The synthesis of codeinone enol ethers from thebaine, via acetals of 14beta-bromocodeinone, has been...
The conversiomi of codeine to morphine has beemi shown to occur in man and rat by Adler and Latham (...