This editorial and accompanying themed issue reflect on the centrality of cities to regional development. Focusing on the role and function of cities in processes of innovation, production, distribution, and consumption as both individual sites and as networks of sites of production, they examine classic questions in economic geography about concentration, diffusion, and flows of labor and capital and the policy regimes that govern that movement. They also contribute empirically and theoretically to opening up broader conversations from a global perspective regarding how cities serve as nodes in global networks both anchoring and ultimately locating both global and regional flows of capital and labor. Finally, they identify what is at stake...