The urinary cytokine/chemokine signature of renal hyperfiltration in adolescents with type 1 diabetes.

Har, Ron LH
Reich, Heather N
Scholey, James W
Daneman, Denis
Dunger, David
Moineddin, Rahim
Dalton, R Neil
Motran, Laura
Elia, Yesmino
Deda, Livia
Ostrovsky, Masha
Sochett, Etienne B
Mahmud, Farid H
Cherney, David ZI

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Publication date

January 2014

DOI

10.17863/CAM.49636

Publisher

PLoS One

Language

English

Abstract

OBJECTIVE: Urinary cytokine/chemokine levels are elevated in adults with type 1 diabetes (T1D) exhibiting renal hyperfiltration. Whether this observation extends to adolescents with T1D remains unknown. Our first objective was to determine the relationship between hyperfiltration and urinary cytokines/chemokines in normotensive, normoalbuminuric adolescents with T1D using GFR(cystatin). Our second aim was to determine the relationship between urine and plasma levels of inflammatory biomarkers, to clarify the origin of these factors. METHODS: Urine and serum cytokines/chemokines (Luminex platform) and GFR(cystatin) were measured in normofiltering (n = 111, T1D-N, GFR<135 ml/min/1.73 m(2)) and hyperfiltering (n = 31, T1D-H, GFR ≥ 135 ml/min/1...