Anatolicin, a highly potent and selective cytotoxic sesquiterpene coumarin from the root extract of heptaptera anatolica

WOS: 000465503800115PubMed ID: 30909537Seven known sesquiterpene coumarins and a new sesquiterpene coumarin, anatolicin (8), were isolated from the dichloromethane extract of the roots of Heptaptera anatolica. Structures of these compounds were elucidated based on their spectral properties. While some of these sesquiterpene coumarins showed modest cytotoxic activity against COLO205, KM12, A498, UO31, and TC32 cancer cell lines, selective cytotoxicity of anatolicin (8) and 14-acetoxybadrakemin (7) were observed at nanomolar level against the UO31 kidney cancer cell line.Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research [1ZIA BC01146907]; National Cancer Institute, National Institutes of Health [HHSN261200800001E]This research was supported in part by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research (1ZIA BC01146907) and with federal funds from the National Cancer Institute, National Institutes of Health, under contract HHSN261200800001