Podwyższenie wartości markerów stresu oksydacyjnego u pacjentów z niealkoholową stłuszczeniową chorobą wątroby z wysokim stężeniem aminotransferazy alaninowej w surowicy

Introduction: Non- alcoholic fatty liver disease (NAFLD) is a pathological disease that causes chronic damage in the liver without alcohol consumption. Aim of the research: To determine oxidative stress and inflammation statuses (NAFLD) with increased alanine aminotransferase (ALT). Material and methods: Oxidative stress (malondialdehyde (MDA), advanced oxidation protein products (AOPP), inflammation (serum tumour necrosis factor-alpha (TNF-alpha)), interleukin-6 (IL-6), and hyaluronic acid (HA) were measured by the ELISA method or manually. A total of 133 non-obese and non-diabetic individuals were included. Patients diagnosed with NAFLD with normal ALT levels were included in group 1 (n = 53), and those with high ALT levels were included in group 2 (n = 35). The control group included individuals without any known systemic disease (n = 45). Results: We found that the serum MDA levels were significantly elevated in group 2 in comparison to the control group (p 0.05). The serum TNF-a and IL-6 levels of group 1 and group 2 were higher than those in the control group (p 0,05). Stężenia TNF-α i IL-6 w surowicy w grupie 1. i 2. były wyższe niż w grupie kontrolnej (p < 0,05). Stężenie HA w surowicy w grupie 2. było istotnie podwyższone w stosunku do pozostałych grup (p < 0,05). Wnioski: W badaniu wykazano podwyższone stężenia HA i MDA u pacjentów z NAFLD z wysokim stężeniem ALT oraz podwyższone stężenia TNF-α i IL-6 u osób z NAFLD z prawidłowym stężeniem ALT