Maternal serum glycodelin levels in preeclampsia and its relationship with the severity of the disease

WOS: 000440610300013PubMed ID: 28738719Purpose: Preeclampsia, in which insufficient trophoblastic invasion is thought to be one of the underlying mechanisms, is a common pregnancy disorder. Glycodelin is a regulator of immunosuppression, fertilization, implantation, and placentation. Because of its inhibitory effects on trophoblastic activity, trophoblast invasion is disturbed when its levels alter. We aimed to analyze serum glycodelin levels in preeclampsia and evaluate whether it correlates with the severity of disease.Methods: This is a prospective case-control study conducted in a research and training hospital between March and September 2016. In this study, a total of 55 preeclamptic and 65 healthy pregnants were included. Preeclamptic patients were divided into two subgroups: 25 severe and 30 mild. Maternal serum glycodelin levels were measured using enzyme-linked immunosorbent assay.Results: Glycodelin levels were higher in preeclamptic group as compared with controls (71.3822.78 versus 42.32 +/- 12.28ng/ml, p53.64ng/ml. Moreover, area under the curve for glycodelin to diagnose severe preeclampsia is 0.788 with p83.97ng/ml.Conclusion: Glycodelin may be a promising marker in predicting the presence and severity of preeclampsia