The study elucidated the combined effect of the formulation parameters (the relative contents of the copolymer (poloxamer 407 (P407)), the cosolvent (isopropyl alcohol), and the hydrophobic drug (ibuprofen)) on gelation, applicative properties, drug solubilization capacity and release kinetics of the P407 aqueous solutions under the common conditions of storage and topical administration. The presence of ibuprofen at a therapeutic concentration of 5% enhanced the increase in micellar volume fraction and allowed the gelation of the liquid solutions at P407 concentrations ≥ 15%. Light microscopy, DSC analysis, and rheological measurements pointed that P407 gels with 15–20% of the copolymer enabled controled precipitation of amorphous ibuprofe...
The objective of this study was to develop sustained release Poloxamer 407 (P407) gel formulations o...
Thermogelling amphiphilic block copolymers have been widely investigated in the development of pharm...
Polysaccharides are attractive gelling agents in pharmacy due to their safety, biocompatibility, bio...
Suitability of liquid lecithin (i.e., solution of lecithin in soy bean oil with similar to 60% w/w o...
The study is focused on formulation of biocompatible hydrogels with a poorly soluble drug ibuprofen ...
A solubility phase study was carried out to investigate the ability of Poloxamer 407 (P407) to solub...
Simple gel formulations may be applied to enhance the systemic and local exposure of potential compo...
Solid dispersions have been employed as a method to improve the dissolution rate and hence the bioav...
Background: Poloxamers are low-toxicity copolymers whose aqueous solutions can pass reversibly from ...
Microcrystalline cellulose (MCC) and cross-linked polyvinylpyrrolidone (PVP-CL) were examined as pol...
The crystallization of nonsteroidal anti-inflammatory drug [2-(4-isobutyl-phenyl) propionic acid] ib...
In this review, we describe the application of thermosensitive hydrogels composed of poloxamer in me...
To develop an industrially practical thermosensitive injectable hydrogel that is easy to administer,...
Pluronic hydrogels containing a weakly acidic hydrophobic API, ibuprofen, at concentration of 1% and...
Poloxamers are negatively temperature-sensitive hydrogels and their hydrophilic groups interact with...
The objective of this study was to develop sustained release Poloxamer 407 (P407) gel formulations o...
Thermogelling amphiphilic block copolymers have been widely investigated in the development of pharm...
Polysaccharides are attractive gelling agents in pharmacy due to their safety, biocompatibility, bio...
Suitability of liquid lecithin (i.e., solution of lecithin in soy bean oil with similar to 60% w/w o...
The study is focused on formulation of biocompatible hydrogels with a poorly soluble drug ibuprofen ...
A solubility phase study was carried out to investigate the ability of Poloxamer 407 (P407) to solub...
Simple gel formulations may be applied to enhance the systemic and local exposure of potential compo...
Solid dispersions have been employed as a method to improve the dissolution rate and hence the bioav...
Background: Poloxamers are low-toxicity copolymers whose aqueous solutions can pass reversibly from ...
Microcrystalline cellulose (MCC) and cross-linked polyvinylpyrrolidone (PVP-CL) were examined as pol...
The crystallization of nonsteroidal anti-inflammatory drug [2-(4-isobutyl-phenyl) propionic acid] ib...
In this review, we describe the application of thermosensitive hydrogels composed of poloxamer in me...
To develop an industrially practical thermosensitive injectable hydrogel that is easy to administer,...
Pluronic hydrogels containing a weakly acidic hydrophobic API, ibuprofen, at concentration of 1% and...
Poloxamers are negatively temperature-sensitive hydrogels and their hydrophilic groups interact with...
The objective of this study was to develop sustained release Poloxamer 407 (P407) gel formulations o...
Thermogelling amphiphilic block copolymers have been widely investigated in the development of pharm...
Polysaccharides are attractive gelling agents in pharmacy due to their safety, biocompatibility, bio...