Add to ORKGA total of 1.7 million traumatic brain injuries (TBIs) occur each year in the UnitedStates, but available pharmacologic options for the treatment of acute neurotraumaare limited. Oxidative stress is an important secondary mechanism of injury that canlead to neuronal apoptosis and subsequent behavioral changes. Using a clinicallyrelevant and validated rodent blast model, we investigated how nicotinamideadenine dinucleotide phosphate oxidase (Nox) expression and associated oxida-tive stress contribute to cellular apoptosis after single and repeat blast injuries.Nox4 forms a complex with p22phox after injury, forming free radicals at neuronalmembranes. Using immunohistochemical-staining methods, we found a visible in-crease in Nox4 after singl...
Nicotinamide adenine dinucleotide phosphate oxidase (NOX) is a multisubunit enzyme complex that util...
Trauma to the brain is a leading cause of death and disability. The primary injury initiates a casca...
The molecular mechanism underlying the selective vulnerability of neurons to oxidative damage caused...
A total of 1.7 million traumatic brain injuries (TBIs) occur each year in the UnitedStates, but avai...
Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Despite intense inv...
Pharmacological interventions for traumatic brain injury (TBI) are limited. Together with parvalbumi...
NADPH oxidases (NOX's), and the reactive oxygen species (ROS) they produce, play an important role i...
Background: NOX2 (nicotinamide adenine dinucleotide phosphate oxidase 2), which is upregulated by a ...
BACKGROUND: Oxidative stress is known to play an important role in the pathology of traumatic brain ...
Traumatic brain injury (TBI) is a leading cause of death and disability TBI survivors often suffer f...
<p><b>A:</b> Confocal images show colocalization of the NOX2 NADPH oxidase isoform and NeuN in cereb...
Abstract Significance: Stroke, a leading cause of death and disability, poses a substantial burden f...
Traumatic brain injury (TBI) is a major cause of mortality and disability. As common sequelae in sur...
), and thereby potentially contribute to the oxidative stress following TBI. The current study thus ...
Blast-induced Traumatic brain injury (bTBI) is a leading cause of morbidity in soldiers on the battl...
Nicotinamide adenine dinucleotide phosphate oxidase (NOX) is a multisubunit enzyme complex that util...
Trauma to the brain is a leading cause of death and disability. The primary injury initiates a casca...
The molecular mechanism underlying the selective vulnerability of neurons to oxidative damage caused...
A total of 1.7 million traumatic brain injuries (TBIs) occur each year in the UnitedStates, but avai...
Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Despite intense inv...
Pharmacological interventions for traumatic brain injury (TBI) are limited. Together with parvalbumi...
NADPH oxidases (NOX's), and the reactive oxygen species (ROS) they produce, play an important role i...
Background: NOX2 (nicotinamide adenine dinucleotide phosphate oxidase 2), which is upregulated by a ...
BACKGROUND: Oxidative stress is known to play an important role in the pathology of traumatic brain ...
Traumatic brain injury (TBI) is a leading cause of death and disability TBI survivors often suffer f...
<p><b>A:</b> Confocal images show colocalization of the NOX2 NADPH oxidase isoform and NeuN in cereb...
Abstract Significance: Stroke, a leading cause of death and disability, poses a substantial burden f...
Traumatic brain injury (TBI) is a major cause of mortality and disability. As common sequelae in sur...
), and thereby potentially contribute to the oxidative stress following TBI. The current study thus ...
Blast-induced Traumatic brain injury (bTBI) is a leading cause of morbidity in soldiers on the battl...
Nicotinamide adenine dinucleotide phosphate oxidase (NOX) is a multisubunit enzyme complex that util...
Trauma to the brain is a leading cause of death and disability. The primary injury initiates a casca...
The molecular mechanism underlying the selective vulnerability of neurons to oxidative damage caused...