It has been well established that peripheral inflammation resulting from microbial infections profoundly alters brain function. This review focuses on experimental systems that model cerebral effects of peripheral viral challenge. The most common models employ the induction of the acute phase response (APR) via intraperitoneal injection of a viral mimetic, polyinosinic-polycytidylic acid (PIC). The ensuing transient surge of blood-borne inflammatory mediators induces a “mirror” inflammatory response in the brain characterized by the upregulated expression of a plethora of genes encoding cytokines, chemokines and other inflammatory/stress proteins. These inflammatory mediators modify the activity of neuronal networks leading to a constellati...
Research in the field of neuropsychoimmunology has enabled the researchers to show that cytokines ta...
Human induced pluripotent stem cells (iPSCs), together with 21st century cell culture methods, have ...
Communication between the immune and the nervous system is essential for human brain development and...
A large body of clinical evidence suggests that viral infections in the periphery can exacerbate neu...
Peripheral viral infections are potent comorbid factors that exacerbate neurodegeneration. Althou...
Seizure syndromes are common neuropathologies associated with epilepsy, metabolic disturbances, stro...
We have previously shown that peripherally restricted acute phase response (APR) elicited by intrape...
Systemic inflammation, evoked by an infection or injury leads to the production of inflammatory medi...
Poly inosinic:poly cytidylic acid (poly I:C) is a synthetic double-stranded RNA and is a ligand for ...
BACKGROUND: Chronic neurodegeneration results in microglial activation, but the contribution of infl...
Peripheral viral infections increase seizure propensity and intensity in susceptible individuals. We...
BackgroundChronic neurodegeneration results in microglial activation, but the contribution of inflam...
BackgroundChronic neurodegeneration results in microglial activation, but the contribution of inflam...
Bi-directional communication between the periphery and the central nervous system (CNS) is essential...
AbstractThe role of inflammation in the progression of neurodegenerative disease remains unclear. We...
Research in the field of neuropsychoimmunology has enabled the researchers to show that cytokines ta...
Human induced pluripotent stem cells (iPSCs), together with 21st century cell culture methods, have ...
Communication between the immune and the nervous system is essential for human brain development and...
A large body of clinical evidence suggests that viral infections in the periphery can exacerbate neu...
Peripheral viral infections are potent comorbid factors that exacerbate neurodegeneration. Althou...
Seizure syndromes are common neuropathologies associated with epilepsy, metabolic disturbances, stro...
We have previously shown that peripherally restricted acute phase response (APR) elicited by intrape...
Systemic inflammation, evoked by an infection or injury leads to the production of inflammatory medi...
Poly inosinic:poly cytidylic acid (poly I:C) is a synthetic double-stranded RNA and is a ligand for ...
BACKGROUND: Chronic neurodegeneration results in microglial activation, but the contribution of infl...
Peripheral viral infections increase seizure propensity and intensity in susceptible individuals. We...
BackgroundChronic neurodegeneration results in microglial activation, but the contribution of inflam...
BackgroundChronic neurodegeneration results in microglial activation, but the contribution of inflam...
Bi-directional communication between the periphery and the central nervous system (CNS) is essential...
AbstractThe role of inflammation in the progression of neurodegenerative disease remains unclear. We...
Research in the field of neuropsychoimmunology has enabled the researchers to show that cytokines ta...
Human induced pluripotent stem cells (iPSCs), together with 21st century cell culture methods, have ...
Communication between the immune and the nervous system is essential for human brain development and...