A Study on Prognostic Implication of Hs-CRP In Acute Coronary Syndrome (ACS) patients admitted in Thanjavur Medical College & Hospital

AIMS AND OBJECTIVE: To evaluate the prognostic implication of Hs-CRP in Acute coronary syndrome (ACS) patients admitted in Thanjavur Medical College & Hospital (TMCH). STUDY DESIGN: The study was designed as a prospective biochemical study. METHODOLOGY: 48 acute coronary syndrome patients (both STEMI & NSTEMI) between 25-75 years of age and of both sex, who were admitted in Thanjavur Medical College and Hospital, ICCU&IMCU were included in our study. Based on the clinical presentation, ECG findings and positivity for the cardiac biomarker troponin -T, the diagnosis of acute coronary syndrome (ACS) was established. 7ml of venous blood samples were collected from ACS patients under aseptic conditions and the highly sensitive C reactive protein (Hs-CRP) levels were estimated within 6 hours of admission (baseline) and between 36-48 hours (peak value) of admission. All the 48 acute coronary syndrome (ACS) patients underwent thrombolytic therapy and they were fully interrogated and investigated during the 1 week hospital stay. RESULTS: Pearson’s correlation analysis was done to assess the relationship between baseline and peak values of Hs-CRP and body mass index, lipid profile and Ejection fraction. There was a statistically significant correlation (p < 0.05) between prognosis and Hs-CRP level with a p-value of 0.001 in our study. CONCLUSION: Patients with elevated levels of Hs-CRP had a poor prognosis. Hence, the assessment of Hs-CRP levels may enable the physician in detecting the prognosis of acute coronary syndrome patients and in planning a more prompt and effective reperfusion therapy