A Study on Estimation of Serum Uric Acid in Essential Hypertension

INTRODUCTION: Cardiovascular disease is an important epidemic of the public health. SHT is one of important vascular diseases, prevalence is about twenty five percent of individuals and increases with older age individuals. The various investigations have proved that SUA has been associated with cardiovascular morbidity and cardiovascular diseases. an attempt has been made to revise the estimation of elevated uric acid levels in essential hypertension and the correlation and association between elevated uric acid levels and hypertensive target organ damage. AIMS AND OBJECTIVE: 1. To study the level of uric acid in patients with essential hypertension. 2. To identify whether any association exists between ages, sex, body mass index, smoking, and target organ damage and the presence of elevated serum uric acid. STUDY DESIGN: Cross sectional study. METHODOLOGY: This study group included total number of 165 subjects. Among these 165 subjects, 110 were cases (hypertensives) and 55 were controls (normotensives). Study was conducted from January 2016 to June 2016. Patients diagnosed with ESSENTIAL HYPERTENSION coming to Thanjavur medical college & hospital , who satisfy the inclusion criteria are subjected to detailed history, clinical examination, and investigations. OBSERVATION AND RESULTS: In our study Among the 110 cases of hypertension, hyperuricemia was seen in 16 cases, which is account for 14% of cases. In study groups, The mean serum uric acid level in cases is 5.442mg/dl while in the control it is 4.084mg/dl. The mean serum uric acid level in cases with CAD is 6.024±0.02 while it is 5.023±0.01 among the cases without CAD. This is consistent with other studies, which has shown serum uric acid is elevated in hypertension. that uric acid level in patients with TOD is significantly elevated compared with those without TOD. CONCLUSION: Hyperuricemia (>7mg/dl in males and >6mg/dl in females) is found in 14% of hypertensives while none of the normotensives had hyperuricemia. Serum uric acid level is significantly elevated in Essential hypertension. There is no correlation between serum uric acid with gender, body mass index, smoking. Serum uric acid level is significantly elevated in cases with coronary artery disease as compared to those with other target organ damage