Interferon-g-Inducible Protein 10 for Diagnosis of Tuberculosis in Children

Firmanti, Stefani Candra
Triasih, Rina
Wibawa, Tri
Haryana, Sofia Mubarika

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Publication date

March 2020

DOI

10.18585/inabj.v12i1.973

Publisher

Secretariat of The Indonesian Biomedical Journal

Language

English

Abstract

BACKGROUND: The diagnosis of tuberculosis (TB) in children is challenging by the absence of a practical gold standard. Interferon (IFN)-ginducible protein 10 (IP-10) is a chemokine that may serve as the leading candidate marker in child TB diagnosis. The aim of this study is to assess the diagnostic value of IP-10 in the diagnosis of TB in children.METHODS: We recruited eligible symptomatic and asymptomatic children aged <15 years actively by contact investigation and passively from inpatient and outpatient clinics in two hospitals, in Yogyakarta, Indonesia. We conducted clinical examination and chest X-ray in all eligible children. Sputum smear and the rapid molecular TB test were performed in children with TB symptoms. All participants un...