Light propagation in highly scattering biological tissues analyzed by Green's functions

Biomedical optical techniques of treatment, characterization and surgery are strongly dependent on light propagation in tissues. Information that goes beyond pure intensity, such as polarization or other coherence parameters, can provide increased contrast. This contrast is critical in clinical applications, as malignant tissue has to be distinguished from healthy one, or a particular component or structure has to be highlighted and detected. The appropriate consideration of these further light-tissue interaction properties requires taking into account phase and coherence. The complexity of the problem increases as biological tissues present usually high scattering. This fact greatly influences optical propagation, and is usually a fundamental limitation in optical diagnostic techniques. Light propagation in static scattering media can be analyzed by Green's functions. Electromagnetic propagation could be then considered, including coherence phenomena. However, analytical solutions are complex and require usually numerical methods to obtain a result. Monte Carlo approaches are particularly well-suited in biological tissues. In this work light propagation in highly scattering biological tissues is analyzed first by Green's functions. The limited geometry of this analytical approach serves as a first approach for more complex structures. More realistic biological tissue models are proposed and solved via a threedimensional time-resolved Monte Carlo approach. The model is applied to dermatological tumoral tissues. The results of scattering by Green's functions and the Monte Carlo approach are compared, and the potential contrast of coherence parameters is analyzed in diagnostic applications.This work has been partially supported by the project “New active phases in transition metals and rare earth nano-oxides stabilized at high pressure” (MAT2015-69508-P) of the Spanish Ministry of Economy and Competitiveness, cofunded by FEDER funds, and by the San Cándido Foundation