Meta-analysis of epilepsy prevalence in West Africa and its relationship with onchocerciasis endemicity and control

International audienceBackground: A high prevalence and incidence of epilepsy has been reported in onchocerciasis-endemic regionsin Central and East Africa. There is compelling epidemiological evidence suggesting that this high burden iscaused by onchocerciasis-associated epilepsy (OAE).We hypothesized that OAE had also occured inWest Africanonchocerciasis foci.Methods: We searched PubMed, the African Journals Online platform and grey literature for population-basedepilepsy studies inWest African countries. Epilepsy and onchocerciasis prevalence data were extracted. The precontrolonchocerciasis endemicity in the study siteswas estimated from historical data of onchocerciasis controlprogrammes. The prevalence of epilepsy in different sites was analysed, taking into account onchocerciasisendemicity and the duration of control.Results: The pooled prevalence of epilepsy in theWest African study sites was 13.14 per 1000 (95% confidenceinterval 11.28–15.00). Higher pre-control endemicity and a shorter duration of onchocerciasis control were bothassociated with increased epilepsy prevalence (p