Add to ORKGLeishmaniasis is a neglected disease that affects millions of people worldwide. Poor efficacy and high toxicity of the limited treatment options demonstrate the need for the development of new chemotherapeutic agents to treat this disease. In order to respond this concern, the development of novel Ru-azole complexes as chemotherapeutic agents by inhibiting the cytochrome P-450 dependent C14-α-demethylation of lanosterol to ergosterol which is essential for the parasite survival. In addition, Ruthenium would enhance the activity of the parental drug, by helping ketoconazole/clotrimazole to cross the parasite membrane, together presenting low toxicity. The viability and citotoxicity of the Ru-azole compunds was tested against Leishmania major...
Protozoan parasites from the genus Leishmania cause broad clinical manifestations known as leishmani...
The widespread use of antibiotics has resulted in the emergence of drug-resistant populations of mic...
A series of [RuCl2(p-cymene)(NHC)] complexes were obtained by reacting [RuCl2(p-cymene)]2 with in si...
Leishmaniasis is a neglected disease that affects millions of people worldwide. Poor efficacy and hi...
Four new organoruthenium complexes with formula [RuCl(?6-p-cymene)(?-FCZ)]2[Cl]2 (1), [RuCl(FCZ)(?6-...
The leishmaniasis are considered by the World Health Organization, a disease neglected by many ways,...
<div><p>As part of our efforts to develop organometallic ruthenium compounds bearing activity on bot...
The efficacy of organoruthenium complexes containing ergosterol biosynthesis inhibitors (CTZ: clotri...
Human African trypanosomiasis (sleeping sickness) and leishmaniasis are prevalent zoonotic diseases ...
In the search of new therapeutic tools for the treatment of American Trypanosomiasis, the largest pa...
The complexes trans-[Ru(NO)(NH(3))(4)L](X)(3) (X = BF(4)(-), PF(6)(-) or Cl(-) and L = N-heterocycli...
Artículo de publicación ISIParasitic illnesses are major causes of human disease and misery worldwi...
Leishmaniasis, Chagas disease and malaria are neglected parasitic diseases responsible for high mort...
In the search for new therapeutic tools against neglected diseases produced by trypanosomatid parasi...
Nine organoruthenium complexes with azole antifungal agents (L) clotrimazole (ctz), tioconazole (tcz...
Protozoan parasites from the genus Leishmania cause broad clinical manifestations known as leishmani...
The widespread use of antibiotics has resulted in the emergence of drug-resistant populations of mic...
A series of [RuCl2(p-cymene)(NHC)] complexes were obtained by reacting [RuCl2(p-cymene)]2 with in si...
Leishmaniasis is a neglected disease that affects millions of people worldwide. Poor efficacy and hi...
Four new organoruthenium complexes with formula [RuCl(?6-p-cymene)(?-FCZ)]2[Cl]2 (1), [RuCl(FCZ)(?6-...
The leishmaniasis are considered by the World Health Organization, a disease neglected by many ways,...
<div><p>As part of our efforts to develop organometallic ruthenium compounds bearing activity on bot...
The efficacy of organoruthenium complexes containing ergosterol biosynthesis inhibitors (CTZ: clotri...
Human African trypanosomiasis (sleeping sickness) and leishmaniasis are prevalent zoonotic diseases ...
In the search of new therapeutic tools for the treatment of American Trypanosomiasis, the largest pa...
The complexes trans-[Ru(NO)(NH(3))(4)L](X)(3) (X = BF(4)(-), PF(6)(-) or Cl(-) and L = N-heterocycli...
Artículo de publicación ISIParasitic illnesses are major causes of human disease and misery worldwi...
Leishmaniasis, Chagas disease and malaria are neglected parasitic diseases responsible for high mort...
In the search for new therapeutic tools against neglected diseases produced by trypanosomatid parasi...
Nine organoruthenium complexes with azole antifungal agents (L) clotrimazole (ctz), tioconazole (tcz...
Protozoan parasites from the genus Leishmania cause broad clinical manifestations known as leishmani...
The widespread use of antibiotics has resulted in the emergence of drug-resistant populations of mic...
A series of [RuCl2(p-cymene)(NHC)] complexes were obtained by reacting [RuCl2(p-cymene)]2 with in si...