The most important current anti-influenza weapons, vaccination and antiviral drugs, can be rapidly rendered fully ineffective thanks to the virus’s high mutational rate, which produces viruses exhibiting new antigenic properties and structural proteins insensitive to the drug’s mechanism of action. One attractive alternative is to develop drugs that modulate the activity of cellular systems either required for viral growth or able to neutralize viral growth. Here we demonstrate that the cellular SUMOylation system, a post-translational modification involving the conjugation of the Small Ubiquitin-like MOdifier (SUMO) to specific protein targets using a Ubiquitin-like enzymatic cascade, interacts closely with influenza virus during infection...
The high genetic compatibility between the 2009 H1N1 pandemic swine flu and the highly pathogenic ...
The high genetic compatibility between the 2009 H1N1 pandemic swine flu and the highly pathogenic ...
It is of huge concern the possibility that at some point in the future we may face a new pandemic in...
The most important current anti-influenza weapons, vaccination and antiviral drugs, can be rapidly r...
One of the greatest challenges facing the development of a universal treatment for influenza infecti...
One of the greatest challenges facing the development of a universal treatment for influenza infecti...
The potential for a highly pathogenic influenza pandemic remains a concern for global health. The ab...
The tendency of influenza strains to mutate rapidly, changing their antigenic makeup between consecu...
The potential for a highly pathogenic influenza pandemic remains a concern for global health. The ab...
We have previously shown that the non-structural protein of Influenza A virus NS1A is post-translati...
Influenza virus is a contagious respiratory virus responsible for seasonal epidemics and several cat...
Influenza virus is a contagious respiratory virus responsible for seasonal epidemics and several cat...
Influenza A virus is a negative sense single stranded RNA virus responsible for multiple devastating...
Influenza A virus is a negative sense single stranded RNA virus responsible for multiple devastating...
SUMOylation is an important posttranslational modification for regulation of cellular functions and ...
The high genetic compatibility between the 2009 H1N1 pandemic swine flu and the highly pathogenic ...
The high genetic compatibility between the 2009 H1N1 pandemic swine flu and the highly pathogenic ...
It is of huge concern the possibility that at some point in the future we may face a new pandemic in...
The most important current anti-influenza weapons, vaccination and antiviral drugs, can be rapidly r...
One of the greatest challenges facing the development of a universal treatment for influenza infecti...
One of the greatest challenges facing the development of a universal treatment for influenza infecti...
The potential for a highly pathogenic influenza pandemic remains a concern for global health. The ab...
The tendency of influenza strains to mutate rapidly, changing their antigenic makeup between consecu...
The potential for a highly pathogenic influenza pandemic remains a concern for global health. The ab...
We have previously shown that the non-structural protein of Influenza A virus NS1A is post-translati...
Influenza virus is a contagious respiratory virus responsible for seasonal epidemics and several cat...
Influenza virus is a contagious respiratory virus responsible for seasonal epidemics and several cat...
Influenza A virus is a negative sense single stranded RNA virus responsible for multiple devastating...
Influenza A virus is a negative sense single stranded RNA virus responsible for multiple devastating...
SUMOylation is an important posttranslational modification for regulation of cellular functions and ...
The high genetic compatibility between the 2009 H1N1 pandemic swine flu and the highly pathogenic ...
The high genetic compatibility between the 2009 H1N1 pandemic swine flu and the highly pathogenic ...
It is of huge concern the possibility that at some point in the future we may face a new pandemic in...