Add to ORKGHere, we tested seven 2-acylated-1,4-hydronaphthoquinones for their cytotoxic effects on a panel of cancer lymphoma/leukemia cells and compared to a non-cancer origin cell line. Several naphthohydroquinones exhibited selective cytotoxic effects on lymphoma/leukemia cells with lowest activity on non-cancer cells. The mode of cell death induced by an acylated naphthohydroquinone, which has a long alkyl chain, was found to be via apoptosis. Furthermore, the naphthohydroquinone provoked mitochondria depolarization and activation of its downstream effector, caspase-3, thus implicating the intrinsic apoptotic pathway as its mechanism to exert cell death
The current study describes that nor-β-lapachone and its arylamino derivatives, iodinated and methy...
The 1,4-naphthoquinones, important members of the family of quinones are used as both crude extracts...
A marine polycyclic quinone-type metabolite, halenaquinone (HQ), was found to inhibit the proliferat...
Here, we tested seven 2-acylated-1,4-hydronaphthoquinones for their cytotoxic effects on a panel of ...
Abstract: Novel β-lapachone analogs 2-phenyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione (NQ1), 2-p-to...
Synthesis of compound libraries and their concurrent assessment as selective reagents for probing an...
Synthesis of compound libraries and their concurrent assessment as selective reagents for probing an...
Two novel compounds, 2-(2-hydroxyethylthio)-5,8-dimethoxy-1,4-naphthoquinone (HEDMNQ) and 2-(6-hydro...
This article describes the preparation of 2-heteroaryl and 2,3-diheteroaryl-1,4-naphthoquinones by a...
To examine the effect of hydrophobicity on the anticancer activity of 1,4-naphthoquinone derivative...
Objective. Tetrahydroxyquinone is a molecule best known as a primitive anticataract drug but is also...
Tetrahydroxyquinone is a molecule best known as a primitive anticataract drug but is also a highly r...
AbstractVitamin K-related analogs induce growth inhibition via a cell cycle arrest through cdc25A ph...
Naphthoquinones interact with biological systems by generating reactive oxygen species (ROS) that ca...
The cytotoxicity of a series of aminonaphthoquinones resulting from the reaction of suitable aminoac...
The current study describes that nor-β-lapachone and its arylamino derivatives, iodinated and methy...
The 1,4-naphthoquinones, important members of the family of quinones are used as both crude extracts...
A marine polycyclic quinone-type metabolite, halenaquinone (HQ), was found to inhibit the proliferat...
Here, we tested seven 2-acylated-1,4-hydronaphthoquinones for their cytotoxic effects on a panel of ...
Abstract: Novel β-lapachone analogs 2-phenyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione (NQ1), 2-p-to...
Synthesis of compound libraries and their concurrent assessment as selective reagents for probing an...
Synthesis of compound libraries and their concurrent assessment as selective reagents for probing an...
Two novel compounds, 2-(2-hydroxyethylthio)-5,8-dimethoxy-1,4-naphthoquinone (HEDMNQ) and 2-(6-hydro...
This article describes the preparation of 2-heteroaryl and 2,3-diheteroaryl-1,4-naphthoquinones by a...
To examine the effect of hydrophobicity on the anticancer activity of 1,4-naphthoquinone derivative...
Objective. Tetrahydroxyquinone is a molecule best known as a primitive anticataract drug but is also...
Tetrahydroxyquinone is a molecule best known as a primitive anticataract drug but is also a highly r...
AbstractVitamin K-related analogs induce growth inhibition via a cell cycle arrest through cdc25A ph...
Naphthoquinones interact with biological systems by generating reactive oxygen species (ROS) that ca...
The cytotoxicity of a series of aminonaphthoquinones resulting from the reaction of suitable aminoac...
The current study describes that nor-β-lapachone and its arylamino derivatives, iodinated and methy...
The 1,4-naphthoquinones, important members of the family of quinones are used as both crude extracts...
A marine polycyclic quinone-type metabolite, halenaquinone (HQ), was found to inhibit the proliferat...