HIV–TB coinfection impairs CD8+ T‐cell differentiation and function while dehydroepiandrosterone improves cytotoxic antitubercular immune responses
- Suárez, Guadalupe Verónica
- Angerami, Matias
- Vecchione, María Belén
- Laufer, Natalia Lorna
- Turk, Gabriela Julia Ana
- Ruiz, Maria Julia
- Mesch, Viviana Rosa
- Fabre, Bibiana
- Maidana, Patricia Nieves Amelia
- Ameri, Diego
- Cahn, Pedro
- Sued, Omar Gustavo
- Salomon, Horacio Eduardo
- Bottasso, Oscar Adelmo
- Quiroga, María Florencia
DOIAbstract
Tuberculosis (TB) is the leading cause of death among HIV-positive patients. The decreasing frequencies of terminal effector (TTE ) CD8+ T cells may increase reactivation risk in persons latently infected with Mycobacterium tuberculosis (Mtb). We have previously shown that dehydroepiandrosterone (DHEA) increases the protective antitubercular immune responses in HIV-TB patients. Here, we aimed to study Mtb-specific cytotoxicity, IFN-γ secretion, memory status of CD8+ T cells, and their modulation by DHEA during HIV-TB coinfection. CD8+ T cells from HIV-TB patients showed a more differentiated phenotype with diminished naïve and higher effector memory and TTE T-cell frequencies compared to healthy donors both in total and Mtb-specific CD8+ T ...
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