Formation of foamy macrophages by tuberculous pleural effusions is triggered by the interleukin-10/signal transducer and activator of transcription 3 axis through ACAT upregulation
- Genoula, Melanie
- Marin Franco, Jose Luis
- Dupont, Maeva
- Kviatcovsky, Denise
- Milillo, María Ayelén
- Schierloh, Luis Pablo
- Moraña, Eduardo Jose
- Poggi, Susana
- Palmero, Domingo
- Mata Espinosa, Dulce
- González Domínguez, Erika
- Contreras, Juan Carlos León
- Barrionuevo, Paula
- Rearte, María Bárbara
- Córdoba Moreno, Marlina Olyissa
- Fontanals, Adriana Mirta
- Crotta Asis, Agostina
- Gago, Gabriela Marisa
- Cougoule, Céline
- Neyrolles, Olivier
- Maridonneau Parini, Isabelle
- Sánchez Torres, Carmen
- Hernández Pando, Rogelio
- Vérollet, Christel
- Lugo Villarino, Geanncarlo
- Sasiain, María del Carmen
- Balboa, Luciana
DOIAbstract
The ability of Mycobacterium tuberculosis (Mtb) to persist in its human host relies on numerous immune evasion strategies, such as the deregulation of the lipid metabolism leading to the formation of foamy macrophages (FM). Yet, the specific host factors leading to the foamy phenotype of Mtb-infected macrophages remain unknown. Herein, we aimed to address whether host cytokines contribute to FM formation in the context of Mtb infection. Our approach is based on the use of an acellular fraction of tuberculous pleural effusions (TB-PE) as a physiological source of local factors released during Mtb infection. We found that TB-PE induced FM differentiation as observed by the increase in lipid bodies, intracellular cholesterol, and expression of...
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