Lipids at the crossroad of α-synuclein function and dysfunction: Biological and pathological implications
- Alza, Natalia Paola
- Iglesias González, Pablo Andrés
- Conde, Melisa Ailén
- Uranga, Romina Maria
- Salvador, Gabriela Alejandra
DOIAbstract
Since its discovery, the study of the biological role ofα-synuclein and its pathologicalimplications has been the subject of increasing interest. The propensity to adoptdifferent conformational states governing its aggregation and fibrillation makes thissmall 14-kDa cytosolic protein one of the main etiologic factors associated withdegenerative disorders known as synucleinopathies. The structure, function, and toxicityofα-synuclein and the possibility of different therapeutic approaches to target theprotein have been extensively investigated and reviewed. One intriguing characteristic ofα-synuclein is the different ways in which it interacts with lipids. Though in-depth studieshave been carried out in this field, the information they have p...
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