Circadian variations of prostaglandin E2 and F2 α release in the golden hamster retina
- de Zavalía, Nuria María Asunción
- Fernández, Diego Carlos
- Sande Casal, Pablo Horacio
- Keller Sarmiento, María Inés
- Golombek, Diego Andrés
- Rosenstein, Ruth Estela
- Silberman, Dafne Magalí
DOIAbstract
Circadian variations of prostaglandin E2 and F2α release were examined in the golden hamster retina. Both parameters showed significant diurnal variations with maximal values at midnight. When hamsters were placed under constant darkness for 48 h, the differences in prostaglandin release between subjective mid-day and subjective midnight persisted. Western blot analysis showed that cyclooxygenase (COX)-1 levels were significantly higher at midnight than at mid-day, and at subjective midnight than at subjective mid-day, whereas no changes in COX-2 levels were observed among these time points. Immunohistochemical studies indicated the presence of COX-1 and COX-2 in the inner (but not outer) retina. Circadian variations of retinal prostaglandi...
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