The isoquinolinequinone (IQQ) pharmacophore is a privileged framework in known cytotoxic natural product families, caulibugulones and mansouramycins. Exploiting both families as a chemical starting point, we report on the structured development of an IQQ N-oxide anticancer framework which exhibits growth inhibition in the nM range across melanoma, ovarian and leukaemia cancer cell lines. A new lead compound (16, R6 = benzyl, R7 = H) exhibits nM GI50 values against 31/57 human tumour cell lines screened as part of the NCI60 panel and shows activity against doxorubicin resistant tumour cell lines. An electrochemical study highlights a correlation between electropositivity of the IQQ N-oxide framework and cytotoxicity. Adduct binding to sulfur...
Natural quinones, often linked with cellular oxidation processes, also exhibit pronounced biological...
A series of quinolinequinones bearing various substituents has been synthesized, and the effects of ...
Previously, we discovered a novel class of salicylhydrazide compounds with remarkable activity in ho...
Cancer and antibiotic-resistant bacterial infections are currently two of the major health concerns ...
The major challenge in cancer therapy is to selectively destroy cancer cells in the presence of heal...
Anticancer activity of a series of 3-(hetaryl/aryl)amino substituted isoquinolin-1(2H)-ones has been...
© 2016 The Author(s).The anti-cancer activity of the benzo[h]quinolines was evaluated on cultured hu...
This thesis outlines the design and synthesis of novel chemical routes towards a nascent class of fu...
abstract: Many natural and synthetic quinones have shown biological and pharmacological activity. So...
Quinolone derivatives have recently been introduced as inhibitors of eukaryotic topisomerase-II with...
Copyright © 2014 Penelope Tambama et al. This is an open access article distributed under the Creati...
Objective: Quinones are highly reactive compounds undergoing either one-or two-electron reductions. ...
4-Phenylquinolin-2(1H)-one (4-PQ) derivatives can induce cancer cell apoptosis. Additional new 4-PQ ...
OBJECTIVES: A number of previous studies has provided evidence that the well-known anti-bacterial q...
Cancer is a common, complex, and oftentimes fatal disease. Despite extensive research in the field o...
Natural quinones, often linked with cellular oxidation processes, also exhibit pronounced biological...
A series of quinolinequinones bearing various substituents has been synthesized, and the effects of ...
Previously, we discovered a novel class of salicylhydrazide compounds with remarkable activity in ho...
Cancer and antibiotic-resistant bacterial infections are currently two of the major health concerns ...
The major challenge in cancer therapy is to selectively destroy cancer cells in the presence of heal...
Anticancer activity of a series of 3-(hetaryl/aryl)amino substituted isoquinolin-1(2H)-ones has been...
© 2016 The Author(s).The anti-cancer activity of the benzo[h]quinolines was evaluated on cultured hu...
This thesis outlines the design and synthesis of novel chemical routes towards a nascent class of fu...
abstract: Many natural and synthetic quinones have shown biological and pharmacological activity. So...
Quinolone derivatives have recently been introduced as inhibitors of eukaryotic topisomerase-II with...
Copyright © 2014 Penelope Tambama et al. This is an open access article distributed under the Creati...
Objective: Quinones are highly reactive compounds undergoing either one-or two-electron reductions. ...
4-Phenylquinolin-2(1H)-one (4-PQ) derivatives can induce cancer cell apoptosis. Additional new 4-PQ ...
OBJECTIVES: A number of previous studies has provided evidence that the well-known anti-bacterial q...
Cancer is a common, complex, and oftentimes fatal disease. Despite extensive research in the field o...
Natural quinones, often linked with cellular oxidation processes, also exhibit pronounced biological...
A series of quinolinequinones bearing various substituents has been synthesized, and the effects of ...
Previously, we discovered a novel class of salicylhydrazide compounds with remarkable activity in ho...