The international prevalence and variability of nonadherence to the nonpharmacologic treatment regimen after heart transplantation: Findings from the cross-sectional BRIGHT study

Helmy, Remon
Duerinckx, Nathalie
De Geest, Sabina
Denhaerynck, Kris
Berben, Lut
Russell, Cynthia L
Van Cleemput, Johan
Crespo-Leiro, Maria G
Dobbels, Fabienne

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Publication date

July 2018

DOI

10.1111/ctr.13280

Publisher

Wiley

Journal

Clinical Transplantation

Abstract

INTRODUCTION: Heart transplant (HTx) recipients need to follow a complex therapeutic regimen. We assessed the international prevalence and variability in nonadherence to six nonpharmacologic treatment components (physical activity, sun protection, diet, alcohol use, nonsmoking, and outpatient follow-up visits). METHODS: We used self-report data of 1397 adult HTx recipients from the 36-HTx-center, 11-country, 4-continent, cross-sectional BRIGHT study (ClinicalTrials.gov ID: NCT01608477). The nonadherence definitions used were as follows: Physical activity: 1 alcoholic drink/d (women) or >2 drinks/d (men); Smoking: current smokers or stopped <1 year before; Follow-up visits: missing ≥1 of the last 5 outpatient follow-up visits. Overall preval...