In this work, two projects were pursued. In the first project, I investigated two different subtypes of opioid receptors, which play a key role as target for analgesia. A set of subtype specific fluorescent ligands for μ opioid receptor (MOR) and δ opioid receptor (DOR) was characterised and used to gain insights into the diffusion behaviour of those receptors. It was shown that the novel ligands hold photophysical and pharmacological properties making them suitable for single-molecule microscopy. Applying them to wild-type receptors expressed in living cells revealed that both sub-types possess a heterogeneous diffusion behaviour. Further- more, the fluorescent ligands for the MOR were used to investigate homodomerisation, a highly deb...
For the pharmacological characterization of GPCR ligands in addition to binding data, the determinat...
Der EGF-Rezeptor (engl. epidermal growth factor), auch ErbB1 genannt, gehört zu den Rezeptor-Tyrosin...
This work developed during the first funding period of the subproject B05 in the framework of the in...
In this work, two projects were pursued. In the first project, I investigated two different subt...
G-protein-coupled receptors (GPCRs) represent the largest superfamily of cell surface receptors in t...
Single-molecule microscopy is one of the decisive methodologies that allows one to clarify cellular ...
G protein-coupled receptors (GPCRs) form the biggest receptor family that is encoded in the human ge...
Neuropeptide Y (NPY) is one of the most abundant neuropeptides in the central and peripheral nervous...
G-protein coupled receptors (GPCRs) are the most important class of biological targets of approved p...
In the last three decades, a large amount of experimental data (for example Förster resonance energy...
Das menschliche Gehirn ist ein Organ, das aufgrund seiner Komplexität und zellulären Diversität noch...
About one third of the drugs currently available on the market address cell membrane-integrated G pr...
The core project of the thesis deals with developing a MRI approach for detecting neuronal activity ...
The motivation to understand intermolecular interactions on a fundamental level encourages natural s...
Magnetic resonance imaging (MRI) using contrast agents has been widely employed in diagnostic imagin...
For the pharmacological characterization of GPCR ligands in addition to binding data, the determinat...
Der EGF-Rezeptor (engl. epidermal growth factor), auch ErbB1 genannt, gehört zu den Rezeptor-Tyrosin...
This work developed during the first funding period of the subproject B05 in the framework of the in...
In this work, two projects were pursued. In the first project, I investigated two different subt...
G-protein-coupled receptors (GPCRs) represent the largest superfamily of cell surface receptors in t...
Single-molecule microscopy is one of the decisive methodologies that allows one to clarify cellular ...
G protein-coupled receptors (GPCRs) form the biggest receptor family that is encoded in the human ge...
Neuropeptide Y (NPY) is one of the most abundant neuropeptides in the central and peripheral nervous...
G-protein coupled receptors (GPCRs) are the most important class of biological targets of approved p...
In the last three decades, a large amount of experimental data (for example Förster resonance energy...
Das menschliche Gehirn ist ein Organ, das aufgrund seiner Komplexität und zellulären Diversität noch...
About one third of the drugs currently available on the market address cell membrane-integrated G pr...
The core project of the thesis deals with developing a MRI approach for detecting neuronal activity ...
The motivation to understand intermolecular interactions on a fundamental level encourages natural s...
Magnetic resonance imaging (MRI) using contrast agents has been widely employed in diagnostic imagin...
For the pharmacological characterization of GPCR ligands in addition to binding data, the determinat...
Der EGF-Rezeptor (engl. epidermal growth factor), auch ErbB1 genannt, gehört zu den Rezeptor-Tyrosin...
This work developed during the first funding period of the subproject B05 in the framework of the in...