Many transformed cells exhibit altered glucose metabolism and increased utilization of glutamine for anabolic and bioenergetic processes. These metabolic adaptations, which accompany tumorigenesis, are driven by oncogenic signals. Here we report that the transcription factor c-Jun, product of the proto-oncogene JUN, is a key regulator of mitochondrial glutaminase (GLS) levels. Activation of c-Jun downstream of oncogenic Rho GTPase signalling leads to elevated GLS gene expression and glutaminase activity. In human breast cancer cells, GLS protein levels and sensitivity to GLS inhibition correlate strongly with c-Jun levels. We show that c-Jun directly binds to the GLS promoter region, and is sufficient to increase gene expression. Furthermor...
Glutamine metabolism has a key role in the regulation of uncontrolled tumour growth. This study aime...
One of the major oncogenes dysregulated in breast cancer is MYC. MYC is a master regulator transcrip...
Rapidly proliferating cancer cells have increased biosynthetic and bioenergetic needs compared to qu...
Comment on: Lukey MJ, Greene KS, Erickson JW, et al. The oncogenic transcription factor c-Jun regula...
Efforts to target glutamine metabolism for cancer therapy have focused on the glutaminase isozyme GL...
Increased glutamine metabolism (glutaminolysis) is a hallmark of cancer and is recognised as a key m...
After metabolic reprogramming, many cancer cells become glutamine addicted, that is, they depend on ...
<div><p>Tumor cells display fundamental changes in metabolism and nutrient uptake in order to utiliz...
Tumor cells display fundamental changes in metabolism and nutrient uptake in order to utilize additi...
Objective: Glutamine metabolism is an important pathway in cell proliferation and tumor progression....
Glutaminase (GA) catalyzes the first step in mitochondrial glutaminolysis playing a key role in canc...
Glutaminase (GA) catalyzes the first step in mitochondrial glutaminolysis playing a key role in canc...
SummaryRho GTPases impact a number of activities important for oncogenesis. We describe a small mole...
The targeting of glutamine metabolism specifically via pharmacological inhibition of glutaminase 1 (...
Background: Altered cellular metabolism is a hallmark of cancer and some are reliant on Glutamine fo...
Glutamine metabolism has a key role in the regulation of uncontrolled tumour growth. This study aime...
One of the major oncogenes dysregulated in breast cancer is MYC. MYC is a master regulator transcrip...
Rapidly proliferating cancer cells have increased biosynthetic and bioenergetic needs compared to qu...
Comment on: Lukey MJ, Greene KS, Erickson JW, et al. The oncogenic transcription factor c-Jun regula...
Efforts to target glutamine metabolism for cancer therapy have focused on the glutaminase isozyme GL...
Increased glutamine metabolism (glutaminolysis) is a hallmark of cancer and is recognised as a key m...
After metabolic reprogramming, many cancer cells become glutamine addicted, that is, they depend on ...
<div><p>Tumor cells display fundamental changes in metabolism and nutrient uptake in order to utiliz...
Tumor cells display fundamental changes in metabolism and nutrient uptake in order to utilize additi...
Objective: Glutamine metabolism is an important pathway in cell proliferation and tumor progression....
Glutaminase (GA) catalyzes the first step in mitochondrial glutaminolysis playing a key role in canc...
Glutaminase (GA) catalyzes the first step in mitochondrial glutaminolysis playing a key role in canc...
SummaryRho GTPases impact a number of activities important for oncogenesis. We describe a small mole...
The targeting of glutamine metabolism specifically via pharmacological inhibition of glutaminase 1 (...
Background: Altered cellular metabolism is a hallmark of cancer and some are reliant on Glutamine fo...
Glutamine metabolism has a key role in the regulation of uncontrolled tumour growth. This study aime...
One of the major oncogenes dysregulated in breast cancer is MYC. MYC is a master regulator transcrip...
Rapidly proliferating cancer cells have increased biosynthetic and bioenergetic needs compared to qu...