That reality, and in particular the (dynamic) objects of signs, are independent of our thoughts or other representations is a crucial thesis of Peirce’s realism. On the other hand, his semiotics implies the claim that all reality and all real objects are real for us only because of the signs we use. Do these two claims contradict, even exclude, each other? I will argue that both Peirce’s metaphysics and his semiotics provide a natural via media: a structural account of the openness of processes, featuring transitive relations, connects process ontology implicit in his evolutionary metaphysics and the relational, quasi-inferential features embodied in interpretational sequences of signs. It is shown that Peirce’s notion of a sign, its normat...