This paper seeks to show that the turn toward local scientific practices in the philosophy of science is not a turn away from transcendental investigations. On the contrary, a pragmatist approach can very well be (re)connected with Kantian transcendental examination of the necessary conditions for the possibility of scientific representation and cognition, insofar as the a priori conditions that transcendental philosophy of science examines are understood as historically relative and thus potentially changing. The issue of scientific realism will be considered from this perspective, with special emphasis on Thomas Kuhn's conception of paradigms as frameworks making truth-valued scientific statements possible and on Charles S. Peirce's reali...