We have previously shown that HIV-1-infected children develop broader and more potent neutralizing antibody responses than adults. This study aimed to determine the antibody specificities in 16 HIV-1 subtype C-infected children who displayed exceptional neutralization breadth on a 22-multisubtype virus panel. All children were antiretroviral treatment (ART) naive with normal CD4 counts despite being infected for a median of 10.1 years with high viral loads. The specificity of broadly neutralizing antibodies (bNAbs) was determined using epitope-ablating mutants, chimeric constructs, and depletion or inhibition of activity with peptides and glycoproteins. We found that bNAbs in children largely targeted previously defined epitopes, including ...
AbstractNeutralizing antibody (nAb) response is sporadic and has limited potency and breadth during ...
The study of the evolution and specificities of neutralizing antibodies during the course of human i...
An understanding of how broadly neutralizing activity develops in HIV-1-infected individuals is need...
We have previously shown that HIV-1-infected children develop broader and more potent neutralizing a...
OBJECTIVES: Antibody function has been extensively studied in HIV-infected adults but is relatively ...
Broadly neutralizing antibodies (bNAbs) have demonstrated protective effects against HIV-1 in primat...
A small proportion of HIV-infected individuals generate a neutralizing antibody (NAb) response of ex...
Thesis (Ph.D.)--University of Washington, 2018Developing a protective HIV vaccine remains a key goal...
The targets of broadly cross-neutralizing (BCN) antibodies are of great interest in the HIV vaccine ...
Broadly neutralizing antibodies (bnAbs) against HIV-1 are an effective means of preventing transmiss...
A prophylactic HIV vaccine would ideally induce protective immunity prior to sexual debut. Children ...
Broadly neutralizing antibodies (bnAbs) against HIV-1 are an effective means of preventing transmiss...
Broadly neutralizing antibodies (bNAbs) have remarkable breadth and potency against most HIV-1 subty...
Antibodies that neutralize diverse strains of HIV-1 develop in ∼20% of HIV-1-infected individuals, a...
<div><p>Broadly neutralizing antibodies (bnAbs) are thought to be a critical component of a protecti...
AbstractNeutralizing antibody (nAb) response is sporadic and has limited potency and breadth during ...
The study of the evolution and specificities of neutralizing antibodies during the course of human i...
An understanding of how broadly neutralizing activity develops in HIV-1-infected individuals is need...
We have previously shown that HIV-1-infected children develop broader and more potent neutralizing a...
OBJECTIVES: Antibody function has been extensively studied in HIV-infected adults but is relatively ...
Broadly neutralizing antibodies (bNAbs) have demonstrated protective effects against HIV-1 in primat...
A small proportion of HIV-infected individuals generate a neutralizing antibody (NAb) response of ex...
Thesis (Ph.D.)--University of Washington, 2018Developing a protective HIV vaccine remains a key goal...
The targets of broadly cross-neutralizing (BCN) antibodies are of great interest in the HIV vaccine ...
Broadly neutralizing antibodies (bnAbs) against HIV-1 are an effective means of preventing transmiss...
A prophylactic HIV vaccine would ideally induce protective immunity prior to sexual debut. Children ...
Broadly neutralizing antibodies (bnAbs) against HIV-1 are an effective means of preventing transmiss...
Broadly neutralizing antibodies (bNAbs) have remarkable breadth and potency against most HIV-1 subty...
Antibodies that neutralize diverse strains of HIV-1 develop in ∼20% of HIV-1-infected individuals, a...
<div><p>Broadly neutralizing antibodies (bnAbs) are thought to be a critical component of a protecti...
AbstractNeutralizing antibody (nAb) response is sporadic and has limited potency and breadth during ...
The study of the evolution and specificities of neutralizing antibodies during the course of human i...
An understanding of how broadly neutralizing activity develops in HIV-1-infected individuals is need...