Low-abundance drug-resistant HIV-1 variants in antiretroviral drug-naïve individuals: A systematic review of detection methods, prevalence, and clinical impact
- Mbunkah, Herbert A
- Bertagnolio, Silvia
- Hamers, Raph L
- Hunt, Gillian
- Inzaule, Seth
- Rinke de Wit, Tobias F
- Paredes, Roger
- Parkin, Neil T
- Jordan, Michael R
- Metzner, Karin J
DOIAbstract
BACKGROUND The presence of high-abundance drug-resistant HIV-1 jeopardizes the success of antiretroviral therapy (ART). Despite numerous investigations, the clinical impact of low-abundance drug-resistant HIV-1 variants (LA-DRVs) present at levels <15-25% of the virus population in antitretroviral (ARV) drug-naïve individuals remains controversial. METHODS We systematically reviewed 103 studies assessing the prevalence, detection methods, technical and clinical detection cut-offs, and the clinical significance of LA-DRVs in antiretroviral drug-naïve adults. RESULTS In total, 14,919 ARV drug-naïve individuals were included. The prevalence of LA-DRVs, i.e., the proportion of individuals harboring LA-DRVs, varied between 0 and 1...
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