Abstract

BackgroundThe current study sought to investigate the impact of tumor size and total number of LN examined (TNLE) on the incidence of lymph node metastasis (LNM) among patients with duodenal neuroendocrine tumor (dNET).MethodsPatients who underwent curative resection for dNETs between 1997â 2016 were identified from 8 highâ volume US centers. Risk factors associated with overall survival and LNM were identified and the optimal cutâ off of TNLE relative to LNM was determined.ResultsAmong 162 patients who underwent resection of dNETs, median patient age was 59 (interquartile range [IQR], 51â 68) years and median tumor size was 1.2â cm (IQR, 0.7â 2.0â cm); a total of 101 (62.3%) patients underwent a concomitant LND at the time of surgery. Utilization of lymphadenectomy (LND) increased relative to tumor size (â ¤1â cm:52.2% vs 1â 2â cm:61.4% vs >2â cm:93.8%; Pâ 2â cm:80.0%; Pâ