Emerging Trends in Informationâ Driven Engineering of Complex Biological Systems

Synthetic biological systems are used for a myriad of applications, including tissue engineered constructs for in vivo use and microengineered devices for in vitro testing. Recent advances in engineering complex biological systems have been fueled by opportunities arising from the combination of bioinspired materials with biological and computational tools. Driven by the availability of large datasets in the â omicsâ era of biology, the design of the next generation of tissue equivalents will have to integrate information from singleâ cell behavior to whole organ architecture. Herein, recent trends in combining multiscale processes to enable the design of the next generation of biomaterials are discussed. Any successful microprocessing pipeline must be able to integrate hierarchical sets of information to capture key aspects of functional tissue equivalents. Microâ and biofabrication techniques that facilitate hierarchical control as well as emerging polymer candidates used in these technologies are also reviewed.The engineering of complex biological systems relies on pioneering new tissue designed constructs and microengineered devices to advance regenerative medicine and disease modeling. Modern advances in microâ and biofabrication are fueled by the combination of bioinspired materials with biological and computational tools. The integration of multiscale approaches is discussed to enable nextâ generation biomaterial design.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149723/1/adma201806898_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149723/2/adma201806898.pd