Crystal habit modification of the drug diflunisal that normally grows into extremely thin, long needles has been achieved by breaking the stacking effect with the help of coformers. Eight new cocrystals are reported, along with three crystal structures. In all cases, ortho F disorder, often a feature in diflunisal structures was absent due to the presence of CH···F interactions. Co-milling diflunisal with oxalic acid produced 1:1 and 2:1 cocrystals. In contrast, in solution crystallization, oxalic acid played the role of an additive resulting in the crystallization of diflunisal form I rather than form III. To rationalize cocrystal formation, a statistical analysis of the Cambridge Crystallographic Data Centre database for aromatic o-hydrox...
Solubility enhancement of poorly-soluble active pharmaceutical ingredients (APIs) remains a scientif...
ABSTRACT: Co-crystals consists of API and a stoichiometric amount of a pharmaceutically acceptable c...
Active pharmaceutical ingredients (API) with unfavorable physicochemical properties and stability pr...
Crystal habit modification of the drug diflunisal that normally grows into extremely thin, long need...
Crystal habit modification of the drug diflunisal that normally grows into extremely thin, long need...
The selection of the crystalline phases in a form of molecular cocrystals has become scientific chal...
Cocrystals have recently gained attention as attractive alternate solid forms for drug development. ...
The selection of the crystalline phases in a form of molecular cocrystals has become scientific chal...
This paper describes the combined application of crystal structure prediction and targeted experimen...
Crystal form (cocrystals, polymorphs, salts, hydrates and solvates) assortment remains a scientific ...
Cocrystallisation and salt formation is a widely studied method of optimising the action of Active...
Furosemide (FS), a loop diuretic drug commonly used for the treatment of hypertension and edema, exh...
Cocrystallization became well known bottom-up approach starting from intermolecular interactions amo...
In this paper, we report the crystal growth of four cocrystals of furosemide (4-chloro-2-[(2-furanyl...
Fluoroquinolones are extensively used antibiotics that are generally prescribed as hydrochloride sal...
Solubility enhancement of poorly-soluble active pharmaceutical ingredients (APIs) remains a scientif...
ABSTRACT: Co-crystals consists of API and a stoichiometric amount of a pharmaceutically acceptable c...
Active pharmaceutical ingredients (API) with unfavorable physicochemical properties and stability pr...
Crystal habit modification of the drug diflunisal that normally grows into extremely thin, long need...
Crystal habit modification of the drug diflunisal that normally grows into extremely thin, long need...
The selection of the crystalline phases in a form of molecular cocrystals has become scientific chal...
Cocrystals have recently gained attention as attractive alternate solid forms for drug development. ...
The selection of the crystalline phases in a form of molecular cocrystals has become scientific chal...
This paper describes the combined application of crystal structure prediction and targeted experimen...
Crystal form (cocrystals, polymorphs, salts, hydrates and solvates) assortment remains a scientific ...
Cocrystallisation and salt formation is a widely studied method of optimising the action of Active...
Furosemide (FS), a loop diuretic drug commonly used for the treatment of hypertension and edema, exh...
Cocrystallization became well known bottom-up approach starting from intermolecular interactions amo...
In this paper, we report the crystal growth of four cocrystals of furosemide (4-chloro-2-[(2-furanyl...
Fluoroquinolones are extensively used antibiotics that are generally prescribed as hydrochloride sal...
Solubility enhancement of poorly-soluble active pharmaceutical ingredients (APIs) remains a scientif...
ABSTRACT: Co-crystals consists of API and a stoichiometric amount of a pharmaceutically acceptable c...
Active pharmaceutical ingredients (API) with unfavorable physicochemical properties and stability pr...