Microevolution and Patterns of Transmission of Shigella sonnei within Cyclic Outbreaks of Shigellosis, Israel
- Behar, Adi
- Baker, Kate Susan
- Bassal, Ravit
- Ezernitchi, Analia
- Valinsky, Lea
- Thomson, Nicholas R
- Cohen, Daniel
Publication date
January 2018
DOI Publisher
Centers for Disease Control and Prevention (CDC)Abstract
Whole-genome sequencing unveiled host and environment-related insights to Shigella sonnei transmission within cyclic epidemics during 2000-2012 in Israel. The Israeli reservoir contains isolates belonging to S. sonnei lineage III but of different origin, shows loss of tetracycline resistance genes, and little genetic variation within the O antigen: highly relevant for Shigella vaccine development
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