Early age at natural menopause is related to lower post-bronchodilator lung function: a longitudinal population-based study.

RATIONALE: Poor lung function, a significant predictor of mortality, has been observed in post-menopausal women when compared to those still menstruating. Menopausal age is a risk factor for several adverse health outcomes, but little evidence exists on the impact of menopausal age on lung function impairments, especially on post-bronchodilator lung function measures. OBJECTIVES: Investigate the association between age at menopause and pre- and post-bronchodilator lung function outcomes. METHODS: During the 6th decade follow-up of the Tasmanian Longitudinal Health Study (TAHS) cohort (mean age 53 years), information was collected on most recent menstrual period and menopausal status. Lung function was measured at age 7 and again at 53 years. Multiple linear regression was performed to determine the association between age at menopause and pre- and post-bronchodilator spirometry controlling for early and adult life confounders. RESULTS: Women reporting an early age at natural menopause (