Enantioseparation of binaphthol and its monoderivatives by cyclodextrin-modified capillary zone electrophoresis: A mathematical approach

International audienceA simple model for the separation of atropisomers of binaphthol and its mono derivatives by means of CD-CZE was used. This model described the migration behavior of poly charged enantiomers in a chiral separation system. Thus, this mathematical approach allowed reaching to the optimal cyclodextrin concentrations for the enantioseparation of binaphthols taking into account the influence of the formed complex mobilities. Moreover, using this theoretical approach, the reversal of enantiomers migration order as a function of cyclodextrin concentration could be predicated. At last, the apparent complexation constants between, on the one hand, the cyclodextrins and on the other hand, the binaphthol and its mono derivatives could be calculated using a non-linear curve fitting method and three linear plotting methods (x-reciprocal, y-reciprocal and double reciprocal). Good agreements between the theoretical and experimental cyclodextrin concentrations were obtained