Prion diseases are fatal neurodegenerative disorders caused by an aberrant accumulation of the misfolded cellular prion protein (PrP(C)) conformer, denoted as infectious scrapie isoform or PrP(Sc). In inherited human prion diseases, mutations in the open reading frame of the PrP gene (PRNP) are hypothesized to favor spontaneous generation of PrP(Sc) in specific brain regions leading to neuronal cell degeneration and death. Here, we describe the NMR solution structure of the truncated recombinant human PrP from residue 90 to 231 carrying the Q212P mutation, which is believed to cause Gerstmann-Sträussler-Scheinker (GSS) syndrome, a familial prion disease. The secondary structure of the Q212P mutant consists of a flexible disordered tail (res...
The development of transmissible spongiform encephalopathies (TSEs) is associated with the conversio...
The conversion to a disease-associated conformer (PrP (Sc) ) of the cellular prion protein (PrP (C) ...
Prion diseases or transmissible spongiform encephalopathies (TSEs) are a group of rare neuropathies ...
Prion diseases are fatal neurodegenerative disorders caused by an aberrant accumulation of the misfo...
Prion diseases are a group of neurodegenerative disorders that can arise spontaneously, through infe...
Prion diseases are a group of neurodegenerative disorders that can arise spontaneously, through infe...
Prion diseases belong to a group of fatal neurodegenerative disorders caused by the conversion of th...
Prion diseases belong to a group of fatal neurodegenerative disorders caused by the conversion of th...
The post-translational conversion of the ubiquitously expressed cellular form of the prion protein, ...
Transmissible spongiform encephalopathies (TSEs) are a rare group of rapidly progressive, invariably...
Prion diseases are a group of fatal neurodegenerative disorders that can be of sporadic, genetic or ...
The post-translational conversion of the ubiquitously expressed cellular form of the prion protein, ...
Prion diseases or transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative disor...
The development of transmissible spongiform encephalopathies (TSEs) is associated with the conversio...
The development of transmissible spongiform encephalopathies (TSEs) is associated with the conversio...
The development of transmissible spongiform encephalopathies (TSEs) is associated with the conversio...
The conversion to a disease-associated conformer (PrP (Sc) ) of the cellular prion protein (PrP (C) ...
Prion diseases or transmissible spongiform encephalopathies (TSEs) are a group of rare neuropathies ...
Prion diseases are fatal neurodegenerative disorders caused by an aberrant accumulation of the misfo...
Prion diseases are a group of neurodegenerative disorders that can arise spontaneously, through infe...
Prion diseases are a group of neurodegenerative disorders that can arise spontaneously, through infe...
Prion diseases belong to a group of fatal neurodegenerative disorders caused by the conversion of th...
Prion diseases belong to a group of fatal neurodegenerative disorders caused by the conversion of th...
The post-translational conversion of the ubiquitously expressed cellular form of the prion protein, ...
Transmissible spongiform encephalopathies (TSEs) are a rare group of rapidly progressive, invariably...
Prion diseases are a group of fatal neurodegenerative disorders that can be of sporadic, genetic or ...
The post-translational conversion of the ubiquitously expressed cellular form of the prion protein, ...
Prion diseases or transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative disor...
The development of transmissible spongiform encephalopathies (TSEs) is associated with the conversio...
The development of transmissible spongiform encephalopathies (TSEs) is associated with the conversio...
The development of transmissible spongiform encephalopathies (TSEs) is associated with the conversio...
The conversion to a disease-associated conformer (PrP (Sc) ) of the cellular prion protein (PrP (C) ...
Prion diseases or transmissible spongiform encephalopathies (TSEs) are a group of rare neuropathies ...