Polydiacetylenic nanofibers as new siRNA vehicles for in vitro and in vivo delivery
- Neuberg, P. (Patrick)
- Hamaidi, I.
- Danilin, S.
- Ripoll, M. (Manon)
- Lindner, V.
- Nothisen, M. (Marc)
- Wagner, A. (Alain)
- Kichler, A. (Antoine)
- Massfelder, T.
- Remy, J. (Jean-Serge)
Publication date
January 2018
DOI Publisher
Royal Society of Chemistry (RSC) Language
EnglishAbstract
Polydiacetylenic nanofibers (PDA-Nfs) obtained by photopolymerization of surfactant 1 were optimized for intracellular delivery of small interfering RNAs (siRNAs). PDA-Nfs/siRNA complexes efficiently silenced the oncogene Lim-1 in the renal cancer cells 786-O in vitro. Intraperitoneal injection of PDA-Nfs/siLim1 downregulated Lim-1 in subcutaneous tumor xenografts obtained with 786-O cells in nude mice. Thus, PDA-Nfs represent an innovative system for in vivo delivery of siRNAs
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