Bisphenol-A in Wistar Rats: Toxicological Study as Mitochondrial Disrupting Agent

BPA is an EDC which is continuously released into the environment because of its extensive usage as plasticizer and other industrial applications. The present study establishes BPA induced alterations in mitochondrial marker enzymes and hence cause mitochondrial dysfunction. Studies were performed to evaluate the histopathological changes in tissue on exposure to different doses of BPA for different time periods.  Light microscopic examination of samples was done to evaluate the possible changes caused by treatment of different doses of BPA. After getting the results in light microscopy the changes and damage caused by BPA ultra-structurally were observed.  Light microscopic study showed that BPA exposure for short duration of 7 days did not resulted in significant change in histology of Rat of treated animals. Light microscopic observations showed that low doses of BPA (5 and 10 mg/kg body weight) exposure for 14 days caused reduction in the number of cells in the layers of seminiferous tubules. Highest dose of BPA treatment for 14 days caused much damage to the seminiferous tubules. There were many ultra-structural changes found in the treated groups as compared to the control group. Hence it can be stated that due to the toxic effect of BPA the mitochondrial marker enzymes have shown marked reduction in their activities. Keywords: BPA, EDCs, Light microscopic, Mitochondria and Toxicity