Glioblastoma (GB), a grade IV glioma, with high heterogeneity and chemoresistance, obligates a multidimensional antagonist to debilitate its competence. Considering the previous reports on thioesters as antitumor compounds, this paper investigates on use of this densely functionalized sulphur rich molecule as a potent anti-GB agent. Bio-evaluation of 12 novel compounds, containing α-thioether ketone and orthothioester functionalities, identified that five analogs exhibited better cytotoxic profile compared to standard drug cisplatin. Detailed toxicity studies of top compound were evaluated in two cell lines, using cell viability test, apoptotic activity, oxidative stress and caspase activation and RNA-sequencing analysis, to obtain a compre...
International audienceGlioblastoma (GBM) is the most frequent and aggressive primary tumor of the br...
Substituted thiourea derivatives possess confirmed cytotoxic activity towards cancer but also normal...
In my doctoral work, I have been concerned to identify new targets involved in solid tumors. That be...
Glioblastoma (GB), a grade IV glioma, with high heterogeneity and chemoresistance, obligates a multi...
Frequent relapses and therapeutic resistance make the management of glioblastoma (GBM, grade IV glio...
Frequent relapses and therapeutic resistance make the management of glioblastoma (GBM, grade IV glio...
Sulforaphane, a naturally occurring isothiocyanate, has gained attention due to its tremendous antic...
Abstract AIMS GSK3β is a constitutively conserved serine/threonine kinase involved in a number of bi...
Glioblastoma is the most common of all tumors in the brain and central nervous system and has an ave...
Glioblastoma (GB) is the most common and aggressive primary tumor of the central nervous system. The...
Thiouracil and thiocytosine are important heterocyclic pharmacophores having pharmacological diversi...
OBJECTIVE Defects in the apoptotic machinery and augmented survival signals contribute to drug resi...
Glioblastoma (GBM), a malignant brain tumor, is one of the most aggressive human neoplasms due to it...
Glioblastoma is the most common primary brain tumor which has a median survival of only 14.6 months....
Glioblastoma is the most malignant form of brain cancer. Due to its aggressive nature, extensive res...
International audienceGlioblastoma (GBM) is the most frequent and aggressive primary tumor of the br...
Substituted thiourea derivatives possess confirmed cytotoxic activity towards cancer but also normal...
In my doctoral work, I have been concerned to identify new targets involved in solid tumors. That be...
Glioblastoma (GB), a grade IV glioma, with high heterogeneity and chemoresistance, obligates a multi...
Frequent relapses and therapeutic resistance make the management of glioblastoma (GBM, grade IV glio...
Frequent relapses and therapeutic resistance make the management of glioblastoma (GBM, grade IV glio...
Sulforaphane, a naturally occurring isothiocyanate, has gained attention due to its tremendous antic...
Abstract AIMS GSK3β is a constitutively conserved serine/threonine kinase involved in a number of bi...
Glioblastoma is the most common of all tumors in the brain and central nervous system and has an ave...
Glioblastoma (GB) is the most common and aggressive primary tumor of the central nervous system. The...
Thiouracil and thiocytosine are important heterocyclic pharmacophores having pharmacological diversi...
OBJECTIVE Defects in the apoptotic machinery and augmented survival signals contribute to drug resi...
Glioblastoma (GBM), a malignant brain tumor, is one of the most aggressive human neoplasms due to it...
Glioblastoma is the most common primary brain tumor which has a median survival of only 14.6 months....
Glioblastoma is the most malignant form of brain cancer. Due to its aggressive nature, extensive res...
International audienceGlioblastoma (GBM) is the most frequent and aggressive primary tumor of the br...
Substituted thiourea derivatives possess confirmed cytotoxic activity towards cancer but also normal...
In my doctoral work, I have been concerned to identify new targets involved in solid tumors. That be...