Computational methods based on X-ray microtomography for quantitative analysis of lyophilized products

In this work, X-ray microcomputed tomography is used to analyse and reconstruct the inner structure of lyophilized products. Various computational methods were used to determine the structural parameters that impact on mass transport of vapor during drying, i.e., pore size, tortuosity, and permeability. These methods include slice-by-slice 2D image analysis of the entire sample, 3D image analysis of small portions of the product and CFD simulations