Add to ORKGFallopian tube secretory epithelial cells (FTSECs) are likely the main precursor cell type of high-grade serous ovarian cancers (HGSOCs), but these tumors may also arise from ovarian surface epithelial cells (OSECs). We profiled global landscapes of gene expression and active chromatin to characterize molecular similarities between OSECs (n = 114), FTSECs (n = 74), and HGSOCs (n = 394). A one-class machine learning algorithm predicts that most HGSOCs derive from FTSECs, with particularly high FTSEC scores in mesenchymal-type HGSOCs (
Background: High-grade serous ovarian cancer (HGSOC) is a major unmet need in oncology. The remainin...
Background: High-grade serous ovarian cancer (HGSOC) is a major unmet need in oncology. The remainin...
Epithelial ovarian cancer (EOC) is a heterogeneous disease with five histotypes: serous (high-grade ...
Fallopian tube secretory epithelial cells (FTSECs) are likely the main precursor cell type of high-g...
Understanding the regulatory landscape of the human genome is a central question in complex trait ge...
Understanding the regulatory landscape of the human genome is a central question in complex trait ge...
Understanding the regulatory landscape of the human genome is a central question in complex trait ge...
Understanding the regulatory landscape of the human genome is a central question in complex trait ge...
Understanding the regulatory landscape of the human genome is a central question in complex trait ge...
High grade serous ovarian cancer (HGSC), the most lethal and frequent type of epithelial ovarian can...
Understanding the regulatory landscape of the human genome is a central question in complex trait ge...
The human fallopian tube harbors the cell of origin for the majority of high-grade serous "ovarian" ...
Abstract Background Accumulating evidence suggests that somatic stem cells undergo mutagenic transfo...
Germline or somatic mutation(s) in BRCA1 is associated with a 40-50% lifetime risk of developing hig...
Contains fulltext : 154725.pdf (publisher's version ) (Closed access)Understanding...
Background: High-grade serous ovarian cancer (HGSOC) is a major unmet need in oncology. The remainin...
Background: High-grade serous ovarian cancer (HGSOC) is a major unmet need in oncology. The remainin...
Epithelial ovarian cancer (EOC) is a heterogeneous disease with five histotypes: serous (high-grade ...
Fallopian tube secretory epithelial cells (FTSECs) are likely the main precursor cell type of high-g...
Understanding the regulatory landscape of the human genome is a central question in complex trait ge...
Understanding the regulatory landscape of the human genome is a central question in complex trait ge...
Understanding the regulatory landscape of the human genome is a central question in complex trait ge...
Understanding the regulatory landscape of the human genome is a central question in complex trait ge...
Understanding the regulatory landscape of the human genome is a central question in complex trait ge...
High grade serous ovarian cancer (HGSC), the most lethal and frequent type of epithelial ovarian can...
Understanding the regulatory landscape of the human genome is a central question in complex trait ge...
The human fallopian tube harbors the cell of origin for the majority of high-grade serous "ovarian" ...
Abstract Background Accumulating evidence suggests that somatic stem cells undergo mutagenic transfo...
Germline or somatic mutation(s) in BRCA1 is associated with a 40-50% lifetime risk of developing hig...
Contains fulltext : 154725.pdf (publisher's version ) (Closed access)Understanding...
Background: High-grade serous ovarian cancer (HGSOC) is a major unmet need in oncology. The remainin...
Background: High-grade serous ovarian cancer (HGSOC) is a major unmet need in oncology. The remainin...
Epithelial ovarian cancer (EOC) is a heterogeneous disease with five histotypes: serous (high-grade ...