© 2019, The Author(s). Heparin-induced thrombocytopenia (HIT) is a complication of heparin therapy sometimes associated with thrombosis. The hallmark of HIT is antibodies to the heparin/platelet factor 4 (PF4) complex that cause thrombocytopenia and thrombosis through platelet activation. Despite the clinical importance, the molecular mechanisms and late consequences of immune platelet activation are not fully understood. Here, we studied immediate and delayed effects of the complexes formed by human PF4 and HIT-like monoclonal mouse anti-human-PF4/heparin IgG antibodies (named KKO) on isolated human platelets in vitro. Direct platelet-activating effect of the KKO/PF4 complexes was corroborated by the overexpression of phosphatidylserine (P...
Immune heparin-induced thrombocytopenia (HIT) is a potentially serious complication of heparin thera...
International audienceThe diagnosis of heparin-induced thrombocytopenia (HIT) is based on clinical a...
Les thrombopénies induites par l’héparine (TIH) sont une complication sévère des traitements héparin...
© 2020 by the authors. Heparin-induced thrombocytopenia (HIT) is an adverse drug reaction characteri...
Background:Heparin-treated patients often develop antibodies, but only a subset cause heparin-induce...
© 2016 by The American Society of Hematology. Heparin-induced thrombocytopenia (HIT) is characterize...
Abstract Background This is a review article on heparin-induced thrombocytopenia, an adverse effect ...
is a life-threatening, thrombotic disorder associated with development of anti– platelet factor 4 (a...
© 2001 Dr. Chee Ming VunHeparin-induced thrombocytopenia (HIT) is a disorder found in some patients ...
The diagnosis of heparin-induced thrombocytopenia (HIT) is based on clinical and biological criteria...
Heparin-induced thrombocytopenia (HIT) is an autoimmune thrombotic disorder caused by immune complex...
Heparin-induced thrombocytopenia (HIT) is a frequent drug-adverse event caused in the majority of pa...
International audienceBackground Heparin-induced thrombocytopenia (HIT) is typically caused by plate...
Antibodies against platelet factor 4 (PF4), a protein released from alpha-granules of activated plat...
Heparin-induced thrombocytopenia (HIT) is an immune adverse drug-induced reaction characterized by t...
Immune heparin-induced thrombocytopenia (HIT) is a potentially serious complication of heparin thera...
International audienceThe diagnosis of heparin-induced thrombocytopenia (HIT) is based on clinical a...
Les thrombopénies induites par l’héparine (TIH) sont une complication sévère des traitements héparin...
© 2020 by the authors. Heparin-induced thrombocytopenia (HIT) is an adverse drug reaction characteri...
Background:Heparin-treated patients often develop antibodies, but only a subset cause heparin-induce...
© 2016 by The American Society of Hematology. Heparin-induced thrombocytopenia (HIT) is characterize...
Abstract Background This is a review article on heparin-induced thrombocytopenia, an adverse effect ...
is a life-threatening, thrombotic disorder associated with development of anti– platelet factor 4 (a...
© 2001 Dr. Chee Ming VunHeparin-induced thrombocytopenia (HIT) is a disorder found in some patients ...
The diagnosis of heparin-induced thrombocytopenia (HIT) is based on clinical and biological criteria...
Heparin-induced thrombocytopenia (HIT) is an autoimmune thrombotic disorder caused by immune complex...
Heparin-induced thrombocytopenia (HIT) is a frequent drug-adverse event caused in the majority of pa...
International audienceBackground Heparin-induced thrombocytopenia (HIT) is typically caused by plate...
Antibodies against platelet factor 4 (PF4), a protein released from alpha-granules of activated plat...
Heparin-induced thrombocytopenia (HIT) is an immune adverse drug-induced reaction characterized by t...
Immune heparin-induced thrombocytopenia (HIT) is a potentially serious complication of heparin thera...
International audienceThe diagnosis of heparin-induced thrombocytopenia (HIT) is based on clinical a...
Les thrombopénies induites par l’héparine (TIH) sont une complication sévère des traitements héparin...