Platelets and hepatocellular cancer: Bridging the bench to the clinics
- Lai Q.
- Vitale A.
- Manzia T. M.
- Foschi F. G.
- Sandri G. B. L.
- Gambato M.
- Melandro F.
- Russo F. P.
- Miele L.
- Vigano L.
- Burra P.
- Giannini E. G.
- Aliberti C.
- Baccarani U.
- Bhoori S.
- Borzio M.
- Brancaccio G.
- Cabibbo G.
- Casadei Gardini A.
- Carrai P.
- Cillo U.
- Conti F.
- Cucchetti A.
- D'ambrosio R.
- Dell'unto C.
- Dematthaeis N.
- Di Costanzo G. G.
- Di Sandro S.
- Fucilli F.
- Galati G.
- Gasbarrini A.
- Giuliante F.
- Ghinolfi D.
- Grieco A.
- Gruttaduria S.
- Guarino M.
- Kostandini A.
- Iavarone M.
- Lenci I.
- Losito F.
- Lupo L. G.
- Mazzocato S.
- Mescoli C.
- Miele L.
- Morisco F.
- Muley M.
- Nicolini D.
- Persico M.
- Pompili M.
- Ponziani F. R.
- Pravisani R.
- Rapaccini G. L.
- Rendina M.
- Renzulli M.
- Rossi M.
- Rreka E.
- Sacco R.
- Sangiovanni A.
- Sessa A.
- Simonetti N.
- Sposito C.
- Tortora R.
- Trevisani F.
- Vigano M.
- Villa E.
- Vincenzi V.
- Violi P.
DOIAbstract
Growing interest is recently being focused on the role played by the platelets in favoring hepatocellular cancer (HCC) growth and dissemination. The present review reports in detail both the experimental and clinical evidence published on this topic. Several growth factors and angiogenic molecules specifically secreted by platelets are directly connected with tumor progression and neo-angiogenesis. Among them, we can list the platelet-derived growth factor, the vascular endothelial growth factor, the endothelial growth factor, and serotonin. Platelets are also involved in tumor spread, favoring endothelium permeabilization and tumor cells' extravasation and survival in the bloodstream. From the bench to the clinics, all of these aspects wer...
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