Screen for potential selective inhibitors of Rho GTPases

van Golen, Kenneth L.Inflammatory breast cancer (IBC) is arguably the most aggressive and deadly form of epithelial breast cancer. IBC is known to be a rapidly growing, distinct form of locally advanced breast cancer that is characterized by primary skin changes like edema, erythema, and peau d’orange (skin dimpling). According to the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program, the incidence rates of IBC are significantly higher among African-American and Hispanic women in comparison to Caucasian and non-Hispanic Caucasian women. Pathologically, IBC develops tumor emboli that invade and block the dermal lymphatics of the skin over the breast. This highly metastatic disease carries a 5- and 10-year disease-free survival rates of <45% and