Understanding and predicting the performance of a fusion reactor in terms of confinement is one of the missing milestones to make fusion energy available. The intrinsic non-linearity of the physics at play makes analytical descriptions uneasy: predictions for the design of future reactors such as ITER are thus based on a combination of extrapolations of empirical scaling laws, analytic work and numerical simulations. The latter have really taken on a central role in supporting the theoretical work and the helping for the interpretation of the experimental data. In the present manuscript, we investigate global confinement properties of turbulent heat transport in a Tokamak with first-principles global and flux-driven gyrokinetic simulations ...