Add to ORKGWe recently reported that β-peptides can form discrete hetero-oligomers in aqueous solution. Here we describe the structure of such an oligomer as determined by X-ray crystallography. The structure of Zwit-1F reveals a homo-octamer of two cupped “hands” composed of both parallel and antiparallel 314-helices. The core of the assembly is composed entirely of solvent-excluded β3-homoleucine residues. The Zwit-1F assembly shares many of the physical characteristics of natural proteins
AbstractMolecular simulations are used to examine the aggregation behavior of several β-peptides in ...
β-Peptides made from L-aspartic acid monomers form a new class of β3-peptides. Here we report the fi...
Solvents play an important role in association and assembly of molecules. Here we studied solvent ef...
We recently described the high-resolution X-ray structure of a helical bundle composed of eight copi...
Proteins composed of α-amino acids are essential components of the machinery required for life. Stan...
We recently described the high-resolution X-ray structure of a helical bundle composed of eight copi...
Over the last 20 years, a large body of work in the literature has focused on the folded structures ...
Peptide self-assembly represents a powerful bottom-up approach to the fabrication of new nanomateria...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2004.Vita.Includes bibli...
SummaryPeptides comprised entirely of β-amino acids, or β-peptides, have attracted substantial inter...
The association of amphipathic α helices in water leads to α-helical-bundle protein structures. Howe...
In the natural peptides, helices are stabilized by hydrogen bonds that point backward along the sequ...
Amyloid oligomers play a central role in Alzheimer’s and other amyloid diseases, and yet the structu...
Abstract: The crystal structure of the synthetic protected oligopeptide Z-(Aib)11-OtBu was determine...
Self-assembling peptides offer a versatile set of tools for bottom-up construction of supramolecular...
AbstractMolecular simulations are used to examine the aggregation behavior of several β-peptides in ...
β-Peptides made from L-aspartic acid monomers form a new class of β3-peptides. Here we report the fi...
Solvents play an important role in association and assembly of molecules. Here we studied solvent ef...
We recently described the high-resolution X-ray structure of a helical bundle composed of eight copi...
Proteins composed of α-amino acids are essential components of the machinery required for life. Stan...
We recently described the high-resolution X-ray structure of a helical bundle composed of eight copi...
Over the last 20 years, a large body of work in the literature has focused on the folded structures ...
Peptide self-assembly represents a powerful bottom-up approach to the fabrication of new nanomateria...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2004.Vita.Includes bibli...
SummaryPeptides comprised entirely of β-amino acids, or β-peptides, have attracted substantial inter...
The association of amphipathic α helices in water leads to α-helical-bundle protein structures. Howe...
In the natural peptides, helices are stabilized by hydrogen bonds that point backward along the sequ...
Amyloid oligomers play a central role in Alzheimer’s and other amyloid diseases, and yet the structu...
Abstract: The crystal structure of the synthetic protected oligopeptide Z-(Aib)11-OtBu was determine...
Self-assembling peptides offer a versatile set of tools for bottom-up construction of supramolecular...
AbstractMolecular simulations are used to examine the aggregation behavior of several β-peptides in ...
β-Peptides made from L-aspartic acid monomers form a new class of β3-peptides. Here we report the fi...
Solvents play an important role in association and assembly of molecules. Here we studied solvent ef...