Sperm Quality ANd Testicular Structure of Mus Musculus After Garcinia Mangostana L. Pericarp Extract Administration in Different Polarity

This study was aimed to compare the effect of various doses of Garcinia mangostanapericarp extract using different solvent polarity on mice sperm quality and testicular structure after being exposed to 2- Methoxyethanol. As much as thirty-two mice of BALB/C strain divided into 8 groups (n=4/group); two control groups (negative and positive) and six treatment groups given various extract polarities (nonpolar, semipolar, and polar) anddoses. All treatment was subcutaneously injected daily for 40 days (2-ME for 5 days and Garciniaextract for 35 days). The result showed that Garcinia mangostana pericarp extract on various solvent polarities and doses were able to significantly decreased DNA fragmentation compared to that of positive control group. Other sperm qualities and testosterone level on mice given 0.4 mg/kg of polar extract was found to be higher than the other treatment group. In negative control group, the structureand size of testicle appeared to be thicker. Lumen was also filled with sperm compared to treatment groups. It can be concluded that the administration of polar solvent extract of Garcinia mangostana pericarp at low dose (0.4 mg/Kg) was able to repair decreasing mice sperm quality and testicle structure after 2-ME exposure