Rationale Schizophrenia is associated with prenatal inflammation and/or postnatal stressors such as drug abuse, resulting in immune-redox dysfunction. Antioxidants may offer therapeutic benefits. Objectives The objective of this study is to investigate N-acetyl cysteine (NAC) as a therapeutic antioxidant to reverse schizophrenia-like bio-behavioural changes in rats exposed to maternal immune activation (MIA), adolescent methamphetamine (MA) or a combination thereof. Methods Sprague-Dawley offspring prenatally exposed to saline/lipopolysaccharide (LPS) received saline or MA (0.2–6 mg kg−1 twice daily × 16 days) during adolescence and divided into LPS, MA and LPS + MA groups. Vehicle/NAC (150 mg kg−1 × 14 days) was administered following...
Background Early life stress (ELS) is associated with the development of schizophrenia later in life...
Prenatal adversaries like stress are known to harm the progeny and oxidative stress, which is known ...
Prenatal adversaries like stress are known to harm the progeny and oxidative stress, which is known ...
Schizophrenia is causally associated with early-life environmental stress, implicating oxidative st...
High-fat diet (HFD) consumption during pregnancy is associated with increased oxidative stress (OS) ...
Research in schizophrenia (SZ) emphasizes the need for new therapeutic approaches based on antioxida...
Aims Maternal obesity is associated to increased oxidative stress (OS) representing a risk factor fo...
Maternal obesity may affect foetal programming representing a risk for adult mental health. Oxidativ...
Research in schizophrenia (SZ) emphasizes the need for new therapeutic approaches based on antioxida...
poster abstractSchizophrenia (SZ) is a chronic mental disorder characterized by positive and negativ...
Supplementary data associated with this article can be found, in the online version, at http://dx.d...
Introduction. High-fat diet (HFD) consumption during pregnancy may act as a prenatal stressor affect...
Schizophrenia (SZ) is a chronic mental disorder affecting approximately 1% of the world\u27s populat...
Thesis (MSc (Pharmacology))--North-West University, Potchefstroom Campus, 2013.Methamphetamine (MA) ...
Background Early life stress (ELS) is associated with the development of schizophrenia later in life...
Background Early life stress (ELS) is associated with the development of schizophrenia later in life...
Prenatal adversaries like stress are known to harm the progeny and oxidative stress, which is known ...
Prenatal adversaries like stress are known to harm the progeny and oxidative stress, which is known ...
Schizophrenia is causally associated with early-life environmental stress, implicating oxidative st...
High-fat diet (HFD) consumption during pregnancy is associated with increased oxidative stress (OS) ...
Research in schizophrenia (SZ) emphasizes the need for new therapeutic approaches based on antioxida...
Aims Maternal obesity is associated to increased oxidative stress (OS) representing a risk factor fo...
Maternal obesity may affect foetal programming representing a risk for adult mental health. Oxidativ...
Research in schizophrenia (SZ) emphasizes the need for new therapeutic approaches based on antioxida...
poster abstractSchizophrenia (SZ) is a chronic mental disorder characterized by positive and negativ...
Supplementary data associated with this article can be found, in the online version, at http://dx.d...
Introduction. High-fat diet (HFD) consumption during pregnancy may act as a prenatal stressor affect...
Schizophrenia (SZ) is a chronic mental disorder affecting approximately 1% of the world\u27s populat...
Thesis (MSc (Pharmacology))--North-West University, Potchefstroom Campus, 2013.Methamphetamine (MA) ...
Background Early life stress (ELS) is associated with the development of schizophrenia later in life...
Background Early life stress (ELS) is associated with the development of schizophrenia later in life...
Prenatal adversaries like stress are known to harm the progeny and oxidative stress, which is known ...
Prenatal adversaries like stress are known to harm the progeny and oxidative stress, which is known ...