Metabolic energy management and cancer

Thesis (Ph.D. (Electrical and Electronic Engineering))--North-West University, Potchefstroom Campus, 2012This study examined the energy dependence of cancer cells. Glucose was found to be their main energy source. It seems possible to use this dependence to advantage in the fight against cancer. A novel experiment to reduce the blood glucose supply and utilisation was proposed. It entailed caloric restriction, suppression of glucose secretion by the liver as well as suppression of stress hormones (which elevates glucose levels). This minimises the blood glucose value. As a last step, anti-insulin is provided to inhibit cancer cells to utilise the glucose. The cancer cells are thus deprived of their main energy source. This should lead to a reduction or elimination of tumours and will aid in preventing their development. Although feasible, this method turned out to be too expensive to perform the necessary clinical trials to prove the hypothesis. Next, the focus shifted to cancer prevention. The human energy system was analysed with the goal to reduce the circulating glucose level. The main focus here was metabolised CHO energy consumption. A previously proposed unit – the Equivalent Teaspoon Sugar, or ets , was used to quantify energy with. It was shown that cancer risk increases significantly when the recommended ets consumption per day is exceeded. Furthermore, it was shown that including fibre in a meal reduces the ets value of the meal. One gram of fibre leads to a reduction of around 0.6 ets . The link between exercise, stress, fibre, their resulting blood glucose levels and cancer were quantified in terms of ets . Exercise expends ets , while stress causes the liver to secrete more ets . Experimental data was analysed to confirm the relationships. In conclusion an equation was formulated to describe the combined effect of all these elements on the energy system. One’s total daily ets consumption can be obtained from the equation, and it was linked to one’s cancer risk. Adapting a lifestyle that ensures the correct daily ets intake will lead to a significant reduction in cancer risk. This study proved that cancer cells are very dependent on sugar and a restriction of this energy source forces them into regression. Using this knowledge to advantage may help in the combat one of the biggest killers of our time – cancer.Doctora