Combined testing of copeptin and high-sensitivity cardiac troponin T at presentation in comparison to other algorithms for rapid rule-out of acute myocardial infarction.
- Mueller-Hennessen, Matthias
- Lindahl, Bertil
- Giannitsis, Evangelos
- Vafaie, Mehrshad
- Biener, Moritz
- Haushofer, Alexander C
- Seier, Josef
- Christ, Michael
- Alquézar-Arbé, Aitor
- deFilippi, Christopher R
- McCord, James
- Body, Richard
- Panteghini, Mauro
- Jernberg, Tomas
- Plebani, Mario
- Verschuren, Franck
- French, John K
- Christenson, Robert H
- Dinkel, Carina
- Katus, Hugo A
- Mueller, Christian
DOIAbstract
BACKGROUND: We aimed to directly compare the diagnostic and prognostic performance of a dual maker strategy (DMS) with combined testing of copeptin and high-sensitivity (hs) cardiac troponin T (cTnT) at time of presentation with other algorithms for rapid rule-out of acute myocardial infarction (AMI). METHODS: 922 patients presenting to the emergency department with suspected AMI and available baseline copeptin measurements qualified for the present TRAPID-AMI substudy. Diagnostic measures using the DMS (copeptin <10, <14 or < 20 pmol/L and hs-cTnT≤14 ng/L), the 1 h-algorithm (hs-cTnT<12 ng/L and change <3 ng/L at 1 h), as well as the hs-cTnT limit-of-blank (LoB, <3 ng/L) and -detection (LoD, <5 ng/L) were compared. Outcomes were assessed a...
Add to ORKG